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Old 05-17-2013
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Drug confusion in pharma

Guys can you please answer these questions?

1) Why beta blocker increase lipids?
2) Why propranolol for essential tremor..
3) Why temolol & epinephrine both for glaucoma in lipincott they said epinephrine also treat glaucoma..

4) Kaplan says ischemic cells are partly depolarized so less active Na channel and less conduction BUT according to brs physio ischemic cells have more Ca so increased automaticity..

I think if cell is less hyperpolarize then it can produce AP in response to little stimulus BUT kaplan says increase hyperpolarizatiin increase conduction..

5)B agonist or blocker for HF? Kaplan only mentioned beta agonists while lipincott said beta blocker and why?
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Old 05-18-2013
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You are not restricted to answer all of em. :-D
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Old 05-18-2013
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Quote:
Originally Posted by medicalbiology View Post
Guys can you please answer these questions?

1) Why beta blocker increase lipids?
2)Why propranolol for essential tremor..
3)Why temolol & epinephrine both for glaucoma in lipincott they said epinephrine also treat glaucoma..

4)Kaplan says ischemic cells are partly depolarized so less active Na channel and less conduction BUT according to brs physio ischemic cells have more Ca so increased automaticity..

I think if cell is less hyperpolarize then it can produce AP in response to little stimulus BUT kaplan says increase hyperpolarizatiin increase conduction..

5)B agonist or blocker for HF? Kaplan only mentioned beta agonists while lipincott said beta blocker and why?

B1 effects ( Gq via IP3 ) results in increased lipolysis. So if you block that, there will be less lipolysis and thus an increase in lipids.
Propranolol for essential? Not sure, but probably due to decreased sympathetic activity by the drug

I don't understand your 3rd question, but epinephrine's alpha effects will cause vasoconstriction and reduce production of aqueous
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Old 05-18-2013
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Quote:
Originally Posted by GamX View Post
B1 effects ( Gq via IP3 ) results in increased lipolysis. So if you block that, there will be less lipolysis and thus an increase in lipids.
Propranolol for essential? Not sure, but probably due to decreased sympathetic activity by the drug

I don't understand your 3rd question, but epinephrine's alpha effects will cause vasoconstriction and reduce production of aqueous
B1 effects Gs via cAMP pathway, not Gq. Sorry rushed the above post
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Old 05-18-2013
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Thanxz gamx... i meant epineprine is beta agonist while temolol is beta antagonist but both are reducing aquous humour ...how
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Old 10-06-2013
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In heart failure, beta blockers esp. metoprolol, bisoprolol, carvedilol are useful not beta agonist. Also beta blockers are not recommended in acute stage of heart failure. It is given once the acute stage is over and started at a very low dose and then uptitrated.
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