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Old 05-23-2013
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Question nbme5 doubts??

1. Explanation for HIV variant resistance to antiviral drugs?
a.CD4 is expressed on many cells.
b.HIV can bind many co receptors.
c. HIV reverse transcriptase is error free.
d.Nef is capable of dec cell surface expression of proteins.
e.rev efficiently exports viral mrna frm d nucleus.

2.A RCT compares d efficacy of methotrexate wid placebo fr initiating remission in crohns.
methotrexate placebo
no of patients 40 36
no in remission 26(65%) 14(39%)
Abs risk reduction 26.1%(95 % CI 4.4 to 47.8) p value 0.04. if stdy randomizes 1000 instead of 76. Expected impact on CI??
b decrease
c. inc or dec
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Old 05-23-2013
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1.) If I remember correctly the answer to C should be HIV RTase is error PRONE (not error free) and that should be the answer as it alters drug targets
2.) CI should decrease as it is calculated by:

Mean +/- Z*(SEM)

Where Z is the critical value or border (for 95% you use 1.96 and for 99% 2.58 it is kind of like the number of standard deviations to contain 95% of the data, but this isn't entirely accurate but is a good way to think about it)
SEM is the standard error of the mean calculated by:
SD/√n where n is the sample size
Therefore increasing n, decreases you +/- number and decreases the interval.
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