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Old 05-23-2013
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Default granulomatous vasculitis

in wegeners and churg strauss vasulitis we see necrotizing granuloma! is this caseating? coz i have read that in granuloma if there s necrosis its always caseating!
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Old 05-24-2013
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Granulomatous inflammation not always accompany caseating necrosis ....its typically a feature of tuberculosis ...

in sarcoidosis we have non-caseating granulomas ...

i know a lot of people messes this up .... and as for vasculitis there is never caseating necrosis as far as i know .... its fibrinoid
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Old 05-24-2013
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as for sarcoidosis, there s no necrosis in granuloman so non caseating! Isnt it so, that whenever theres necrosis in granuloma its casseating... as for fibrinoid necrosis theres necrosis without granuloma as in malignant htn and vasculitis of polyarterits nodosa.. my question is wegener s and churg strauss are the only 2 with necrotizing granuloma! now going by the rule of necrosis in granuloma , it should be casseating but its not , why?
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Old 05-24-2013
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Quote:
Originally Posted by cryptococcus View Post
as for sarcoidosis, there s no necrosis in granuloman so non caseating! Isnt it so, that whenever theres necrosis in granuloma its casseating... as for fibrinoid necrosis theres necrosis without granuloma as in malignant htn and vasculitis of polyarterits nodosa.. my question is wegener s and churg strauss are the only 2 with necrotizing granuloma! now going by the rule of necrosis in granuloma , it should be casseating but its not , why?
In rheumatoid arthritis we get rheumatoid nodules .....which are a result of granulomatous inflammation .....but the necrosis in the granuloma is fibrinoid ...check FA ... so not always granulomatous inf. follows caseous necrosis.... and i don't know why it has fibrinoid necrosis in wegeners and churg strauss...but the fact is ... it is ..
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Old 05-24-2013
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But a rule i generally follow is that ....mostly infectious causes of granulomatous inf. usually leads to caseous necrosis ....which inlcudes TB , fungal etc

and other causes not normally does that ... sarcoidosis--no necrosis ....vasculitis and rhematoid---fibrinoid ... etc
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Old 05-24-2013
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thanks npktun! yor answer made things quite clear and thanks for rhematoid arthritis fibrinoid info! din know that!!
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Old 04-22-2014
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i would add too (from pathoma notes):

Fibrinoid necrosis: its necrotic damage to blood vessel wall, due to leaking of proteins (including fibrin) into vessel wall. charcteristic of malignant HTN & Vasculitis. also preeclampsia can cause it in placental blood vessels.

also, necrosis: cells death followed by acute inflammation.
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