Type IV dyslipidemia - Shoulden't Cholesterol also be raised? - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 06-02-2013
USMLE Forums Scout
 
Steps History: Not yet
Posts: 19
Threads: 6
Thanked 26 Times in 6 Posts
Reputation: 36
Biochemistry Type IV dyslipidemia - Shoulden't Cholesterol also be raised?

Greetings again everyone.
I had a query about a table on dyslipidemias in FA. Type IV is due to the oversecretion of VLDL. The table states that there will be elevated blood levels of TG (only) and that there will be increased VLDL.
Aren’t VLDLs composed of TG and Cholesterol? Wouldn’t the level of Cholesterol also be raised, as is the case with Type I (LPL deficiency/C2 deficiency)
Thanks.
Reply With Quote Quick reply to this message



  #2  
Old 06-02-2013
medicalbiology's Avatar
USMLE Forums Guru
 
Steps History: Not yet
Posts: 394
Threads: 128
Thanked 108 Times in 88 Posts
Reputation: 118
Default

According to goljan cholesterol level become 250-500 which is ofcrz very high
Reply With Quote Quick reply to this message
The above post was thanked by:
ashratnam (06-02-2013)
  #3  
Old 06-03-2013
USMLE Forums Addict
 
Steps History: 1+CK+CS
Posts: 101
Threads: 2
Thanked 45 Times in 34 Posts
Reputation: 55
Default

Quote:
Originally Posted by ashratnam View Post
Greetings again everyone.
I had a query about a table on dyslipidemias in FA. Type IV is due to the oversecretion of VLDL. The table states that there will be elevated blood levels of TG (only) and that there will be increased VLDL.
Aren’t VLDLs composed of TG and Cholesterol? Wouldn’t the level of Cholesterol also be raised, as is the case with Type I (LPL deficiency/C2 deficiency)
Thanks.

the major increment would be on TG rather than cholesterol, however cholesterol goes high too.
Reply With Quote Quick reply to this message
  #4  
Old 06-03-2013
USMLE Forums Scout
 
Steps History: Not yet
Posts: 19
Threads: 6
Thanked 26 Times in 6 Posts
Reputation: 36
Default

Quote:
Originally Posted by Fereshteh View Post
the major increment would be on TG rather than cholesterol, however cholesterol goes high too.
Why would that be? If LPL activity is normal, the ability to clear TG from circulation should be intact. You'd expect both to be raised because clearance mechanisms of both are intact, it's just that they're overwhelmed.
Reply With Quote Quick reply to this message
  #5  
Old 06-03-2013
USMLE Forums Addict
 
Steps History: 1+CK+CS
Posts: 101
Threads: 2
Thanked 45 Times in 34 Posts
Reputation: 55
Default

because of overproduction of VLDL, which has a bigger TG portion than cholesterol.
Reply With Quote Quick reply to this message



Reply

Tags
Biochemistry-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
DVT+raised PTT...how will you CONFIRM the dx? tyagee USMLE Step 2 CK Forum 3 06-14-2012 04:56 PM
Fibrates and cholesterol stones No_BS USMLE Step 1 Forum 3 04-17-2012 04:41 AM
Intiating drug t/t in cholesterol? iron USMLE Step 2 CK Forum 2 09-23-2011 05:21 AM
Mechanism of Dyslipidemia in Rx with Beta-Blockers apx85 USMLE Step 1 Forum 1 06-16-2011 05:06 PM
Biostatistics #13 - Probability and cholesterol bebix USMLE Step 1 Forum 7 06-07-2011 07:58 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)