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Old 06-04-2013
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Biochemistry Fructose Intolerance

1. why avoid sorbitol ? i understand why not to give fructose,sucrose
2. why does ATP increases in fructose intolerant liver cell ? see attachment for reference ....


thanks !

p.s.
any relevant usmle step 1 q on similar topic ?
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Fructose Intolerance-pdfstudio_2013-06-05_1.44_01.png  
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Old 06-04-2013
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1st,
cuz sorbitol gets metabolized to fructose by sorbitol dehydrogenase ** in the liver, ovaries, seminal vesicles, and a lil in the lens**
¬also links fructose metab, fructose intolerance, and DM lens changes¬

2nd,
atp doesnt increase. it gets depleted, cuz most of the accumulating fructose gets converted to fructose-1-p >>>inhibition of glycogenolysis and gluconeogenesis>>>hypoglycemia. and the remaining fructose gets peed >>>fructosuria.
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