Originally Posted by medicalbiology
Why there is no anemia in elliptoctosis and Incease MCHC in spherocytosis??
It depends on the type of mutation, although majority do not but with increased erythroid stress (altitude) can result in mild hemolytic anemia. Remember elliptocytosis is a congenital, AD disorder with defective spectrin and/or band 4.1.
Most individuals have a single mutation in one of the spectrin genes so those are asymptomatic, but if the mutation is in both
the genes then yes can result in mild hemolytic anemia (RBC disrupted so destroyed in the spleen) in times of stress.
Key point to note: Spherocytosis is a lot worst because there are multiple mutations (ankyrin, spectrin and band2/3 unlike elliptocytosis) in membrane proteins in the case of hereditary so there is loss of RBC membrane and so decrease in surface/vol ratio hence increasing Hb concentration therefore MCHC.
MCHC: Is the avg haemoglobin concentration in RBC and it's around 33% hb/hct ( Hb X 3= hematocrit) therefore if there is loss of membrane the concentration would increase. Not to confuse with microcytic anemia where there is low mchc (decrease synthesis of hb)
Hope that helps.