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Old 06-07-2013
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Default 30 yo male MPTP exposure

30 year old male drug user with history of MPTP exposure present with tremors at rest, rigidity, and postural instability. direct innervation from sitè of lesion to which nuclei has been damaged?

a. caudate and putamen
b. globus pallidus externus
c. globus pallidus intern us
d. subthalamic nucleus

please give explanation too
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Old 06-07-2013
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Quote:
Originally Posted by saleem khawaja View Post
30 year old male drug user with history of MPTP exposure present with tremors at rest, rigidity, and postural instability. direct innervation from sitè of lesion to which nuclei has been damaged?

a. caudate and putamen
b. globus pallidus externus
c. globus pallidus intern us
d. subthalamic nucleus

please give explanation too
MPTP exposure is an important cause of parkinson syndrome e.g. resting tremor, rigidity, postural instability........so my answer is
a) Caudate and putamen
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Old 06-07-2013
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caudate and putamen..... as it is case of parkinsonism
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Quote:
Originally Posted by saleem khawaja View Post
30 year old male drug user with history of MPTP exposure present with tremors at rest, rigidity, and postural instability. direct innervation from sitè of lesion to which nuclei has been damaged?

a. caudate and putamen
b. globus pallidus externus
c. globus pallidus intern us
d. subthalamic nucleus

please give explanation too
If DIRECT wasn't there, all the answers wud have been correct,
Site of lesion is substantial nigra which sends inhibitory doparminergic effect directly to caudate and putamen
Which is relayed to globes pallidus externus
From there to globes pallidus internus
Then inhibitory signals are sent to the subthalamic nucleus and then projected to the cortex
Correct answer is A (caudate and putamen) DIRECTLY

Last edited by yosky87; 06-07-2013 at 12:26 PM. Reason: Omission
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Old 06-07-2013
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thanks guys. this q was from FA Q and A and answer given is subthalamic nucleus
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Old 06-08-2013
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Quote:
Originally Posted by saleem khawaja View Post
thanks guys. this q was from FA Q and A and answer given is subthalamic nucleus
On this one, I beg to disagree,
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answer is 4 years later but what the heck!
it should be B.
A is huntington.
Globus internus and Subthalamic nuclei are damaged as part of treatment of parkinsonism (also subthalamic damage causes hemibalismus).
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