CSF Protein and Glucose in Meningitis; Why? - USMLE Forums
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Old 06-15-2013
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Question CSF Protein and Glucose in Meningitis; Why?

hi.

Haven't got really understood how high protein! and low glucose in CSF in pat
with Meningitis come. and why is it different in case with infection with virus.

Is there anyone who can clarify it for me!
Thanks in advance.
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Old 06-15-2013
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protein is elevated and glucose in decreased in bacterial meningitis
Viral meningitis normal or slightly decrease

for protein the source of the increase is the bacteria its self which contains high protein in their composition so an increase in protein indicated that there is replicating bacteria , another source is the high large increase in inflammatory cells ( in virus not large increase) these cells contain high protein content

for Glucose , bacteria feed on glucose decreasing it , also due to inflammation , the BBB will become impermeable to glucose causing decrease in glucose level ( in virus the inflammation is not enough to make the barrier impearable )
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Old 06-15-2013
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Quote:
Originally Posted by seliac View Post
protein is elevated and glucose in decreased in bacterial meningitis
Viral meningitis normal or slightly decrease

for protein the source of the increase is the bacteria its self which contains high protein in their composition so an increase in protein indicated that there is replicating bacteria , another source is the high large increase in inflammatory cells ( in virus not large increase) these cells contain high protein content

for Glucose , bacteria feed on glucose decreasing it , also due to inflammation , the BBB will become impermeable to glucose causing decrease in glucose level ( in virus the inflammation is not enough to make the barrier impearable )
Hmm bacterial eating glucose!
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Old 06-16-2013
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Quote:
Originally Posted by nsesereso View Post
Hmm bacterial eating glucose!
lol I know it is funny but it is one of the mechanisms
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Microbiology-, Nervous-System-, Pathology-

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