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Old 06-17-2013
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Default Does blood pressure increase in macrocytic anaemia?

1. Since the mean corpuscular volume increases in macrocytic anaemia ( such as megaloblastic anaemia ) and the bone marrow tries to produce more RBC ( although abnormal ) to compensate anaemia, does this increased number and volume of RBC increases the total blood volume and thus increase blood pressure?

2. I have confusion about the mechanism, because ''Oxford Handbook Of Clinical and Laboratory Investigation'' says that PCV ( or haematocrit, that is, volume occupied by RBC in the blood ) is decreased in all kinds of anaemia regardless of the cause. So, does that mean, the total RBC volume actually decrease in macrocytic anaemia and consequently decrease the total blood volume, and thus cause low blood pressure?

3. Regarding this, I have another confusion. Does PCV indicate only the volume occupied by NORMAL RBC or should the defected RBC be also considered in the measurement of PCV?
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Old 06-17-2013
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I have found the answer.

Actually, in megaloblastic anaemia, most of the megaloblasts are destroyed within the bone marrow. So, PCV is actually decreased.
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