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Old 06-18-2013
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Immunology Concepts of Immunodeficiency Disorders

1. brutons is B cell defect (proB cell >>>\>>> preB cell), then why there is absent thymic shadow ? as mentioned in first aid ???? 2012 edition
2. why PCP pneumonia infection is more common in HIM (hyper IgM has problem with B cell class switching, so bacterial infection not viral infection incidence should rise ... just thinking )
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Old 06-20-2013
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Originally Posted by shoty View Post
1. brutons is B cell defect (proB cell >>>\>>> preB cell), then why there is absent thymic shadow ? as mentioned in first aid ???? 2012 edition
Medscape doesn't mention absense of thymic shadow but other books do.....so I don't know the reason.
Quote:
In the absence of BTK, B lymphocytes do not differentiate or mature. Without mature B lymphocytes, antibody-producing plasma cells are also absent. As a consequence, the reticuloendothelial and lymphoid organs in which these cells proliferate, differentiate, and are stored are poorly developed. The spleen, the tonsils, the adenoids, the Peyer patches in the intestines, and the peripheral lymph nodes may all be reduced in size or absent in individuals with X-linked agammaglobulinemia (XLA).
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Originally Posted by shoty View Post
2. why PCP pneumonia infection is more common in HIM (hyper IgM has problem with B cell class switching, so bacterial infection not viral infection incidence should rise ... just thinking )
Medscape
Because CD40 ligand is required in the functional maturation of T lymphocytes and macrophages, patients with XHIGM also have a variable defect in T-lymphocyte and macrophage effector function. Clinically, patients with XHIGM have increased susceptibility to infection with a wide variety of bacteria, viruses, fungi, and parasites. In addition, they are at increased risk for developing autoimmune disorders and malignancies.
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Old 06-20-2013
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Originally Posted by Novobiocin View Post
Because CD40 ligand is required in the functional maturation of T lymphocytes and macrophages


thanks for this wonderful piece of info

regarding brutons, i going to cram it
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