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Old 06-19-2013
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Kidney GFR and sympathetic stimulation

Can someone please explain effects of sympathetic stimulation on GFR, renal plasma flow and filtration fraction? As I understood from Kaplan lectures- there's increase in FF with decrease in GFR and RPF, but UW says there's no change in GFR in sympathetic stimulation

Last edited by KovachMarina; 06-19-2013 at 07:37 AM.
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Old 06-19-2013
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Sympathetic stimulation constricts predominantly the affarent arterioles with a mild effect on efferent too. Hence GFR and RPF both decrease. The decreased GFR is partly balanced by efferent constriction. Since the drop in RPF is relatively greater it subsequently leads to increase in FF.

PS: FF=GFR\RPF
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Old 06-19-2013
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Quote:
Originally Posted by Dr.Sidd View Post
Sympathetic stimulation constricts predominantly the affarent arterioles with a mild effect on efferent too. Hence GFR and RPF both decrease. The decreased GFR is partly balanced by efferent constriction. Since the drop in RPF is relatively greater it subsequently leads to increase in FF.

PS: FF=GFR\RPF
I understand that and it's quite logical. But according to UW and BRS physiology there's no change in FF?
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