role of NAC in acetaminophen toxicity - USMLE Forums
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Old 06-25-2013
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Drug role of NAC in acetaminophen toxicity

does it helps in making more GSH ( glutathione ) or it itself is free radical scavenger ?
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Old 06-27-2013
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Old 06-27-2013
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Hey man according to Goljan audio notes you give N acetyl cysteine to replenish substrate for glutathione synthesis hence making more gluthathiotone to neutralize acetominaphens free radicals.

Last edited by haseebkat; 06-27-2013 at 02:19 PM.
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Old 06-27-2013
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Mechanism of Action
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NAC is a precursor to glutathione (GSH). It is used as both an antidote for acetaminophen-induced hepatotoxicity and as a mucolytic agent for respiratory diseases. NAC reduces disulphide bonds to sulfhydryl bonds to reduce mucus formation (20). Its hepatoprotective action may occur by cytokine-mediated mechanisms as well as GSH replenishment (21)
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Old 06-27-2013
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Originally Posted by haseebkat View Post
Hey man according to Goljan audio notes you give N acetyl cysteine to replenish substrate for glutathione synthesis hence making more gluthathiotone to neutralize acetominaphens free radicals.
ya i remember, but from biochem videos in kaplan , NAC itself FR scavenger was mentioned....thats why asking....
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Old 06-27-2013
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Default How to assess my qualification

Dear Colleagues

Please bear my very basic question. How can I register and assess my medical qualification from Indonesia ? I am keen on sitting for USMLE exam.

Many Thanks
Anton
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