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Old 11-02-2010
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RBC question - Mature Red Blood Cell

mature rbc
A utilizes lactate dehydrogenase
B utilizes glucose 6 phosphatase
C converts glucose into glycogen
D utilizes pyruvate dehydrogenase

please explain your exclusions
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Old 11-02-2010
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Default It is A

-Mature Rbc utilizes Lactate dehydrogenase (A)
-The fate of glucose in Rbcs in both well fed and fasting states is anaerobic glycolysis (other than HMP shunt),
-Rbcs lack mitochondria hence pyruvate can't be utilized to proceed in
TCA cycle.(choice D)
-Rbcs lack enzymes for Glycogen synthesis which are present in liver and skeletal muscle only (choice C)
-Rbcs lack the enzyme glucose 6 phosphatase which is present only in liver (for Glycogenolysis)(choice B)
This is my understanding, tell me if I'm wrong.
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Old 11-02-2010
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Quote:
Originally Posted by Sparco View Post
-Mature Rbc utilizes Lactate dehydrogenase (A)
-The fate of glucose in Rbcs in both well fed and fasting states is anaerobic glycolysis (other than HMP shunt),
-Rbcs lack mitochondria hence pyruvate can't be utilized to proceed in
TCA cycle.(choice D)
-Rbcs lack enzymes for Glycogen synthesis which are present in liver and skeletal muscle only (choice C)
-Rbcs lack the enzyme glucose 6 phosphatase which is present only in liver (for Glycogenolysis)(choice B)
This is my understanding, tell me if I'm wrong.
nice job dude
u just fished it out
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Old 11-03-2010
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@sparco, u r fantastico

Mature RBC (lacks mitochondria) depends ONLY on anaerobic glycolysis for maintenance of ATP levels sufficient for normal homeostasis. Pyruvate kinase and lactate dehydrogenase are key enzymes of anaerobic glycolysis.
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