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Old 06-28-2013
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Biochemistry substrate level phosphorylation

can some one pleasssssse put some light on substrate level phosphorylation especially in glycolysis , like how many times it happens there...m forgetting it ....
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substrate level phosphorylation is as the name implies when there is production of an energy compound in form of Atp or Ftp directly by formation of one substrate from another without going through the mitochondria (ie oxidative phosphorylation)

an example during glycolysis is the formation of pyruvate from phosphoenolpyruvate(PEP)

Hope this helps..
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substrate level phosphorylation is as the name implies when there is production of an energy compound in form of Atp or Ftp directly by formation of one substrate from another without going through the mitochondria (ie oxidative phosphorylation)

an example during glycolysis is the formation of pyruvate from phosphoenolpyruvate(PEP)

it happens twice can't Remember the 2nd one .check it up in FA.

Hope this helps..
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Old 06-28-2013
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Whenever you have a high energy intermediate, that simply means it contains energy within it's chemical bonds. There are 3 such 'High Energy Intermediates' you should be aware of:

1) 3-Phosphglycerate Kinase
2) Phosphoenol Pyruvate
3) Succinyl-Coa

The high energy contained in the three intermediates above, can be harnessed to make ATP (in the case of the first 2 in glycolysis), or GTP (in the case of the 3rd in the Krebs cycle)

It's called substrate level phosphorylation, because you are ultimately 'phosphoylating ADP --> to make ATP'......and the substrates for this phosphorylation are the high energy intermediates above.

The distinction is important, because in comparison, you have OXIDATIVE phosphorylation, which is what happens when ATP is made using Oxygen as the final electron acceptor in the Electron Transport Chain in the Mitochondria.
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