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  #1  
Old 06-30-2013
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Help NBME 15 Answers need help

pls help me with answers.. exam in a week

1. Role of IkB in NFkB signal transduction pathway from IL1 binding to IL6induction? Its not phosphorylation of NFkB

2. Michelis constant for guanine

3. TGFb traetment causes decrease in no. of normal cells but tumor cells remain unchanged.. mutation of? i thought of APC gene as the q's was on colon cancer and marked tumor progression but its incorrect...

4. point tenderness between abductor pollicis longus and extensor pollicis brevis?

5. diabetic peripheral neuropathy pain type?

6. 2 month old with ABO mismatch plus neutropenia and lymphocytosis... not Congenital CMV..

7. correlation coefficient r= -0.25 between body fat and TLC

8. SLE women with hematologic abnormality... i thought increased ESR but not rouleaux formation ..

9. 6 yr kid with macrorchidism and tanner stage 2 of pubic and axillary hair... height percentile? i thought the q's was on fragile X?

10. bone marrow in 47XY+21 with pancytopenia lethargy bruises pallor fever

11. resistance to protease inhibitor

12. in lysosomal storage disease.. mechanisms of lysosomal enzyme finding? its not degradation of enzymes in cytoplasm

13. histo slide of GE junction . not CMV... i think it will be H.Pylori then

14. shock q's? not cardiogenic not anaphylactic.. i think it will be hypovolemic
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  #2  
Old 06-30-2013
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Help nf kb

nf-kb Activation occurs when it's inhibitor, I-κB, is phosphorylated by specific protein kinase (IKK) & degraded
-Leads to ↑ synthesis of prostaglandins and leukotrienes.

I have not done nbme 15. so can't really help with the other answers as they are abstract and I know its cos of copyright and all and should remain so. I guess some1else would come to your aid soon or our aid as am interested in knowing the answers also.
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I agree

http://quizlet.com/23071157/nbme-15-review-flash-cards/

you should try d link above, they explained some concepts using FA but not writing the questions. please admn should remove my post if it infringes any law.:sorry:
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no 3 should be a tumor suppressor gene either RB or P53 but not sure don't know d options.

no 10 should be ALL or CLL.Downs syndrome most likely ALL.

NO 12.. lysosomal enzymes should be phosphorylated with mannose-6-phosphate in the Golgi apparatus for target into lysosomes within cells or will accumulate in the cytoplasm and cause I cell disease... got a question testing this on the real deal..

no 9 might be precocious puberty.
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  #5  
Old 07-03-2013
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Quote:
Originally Posted by rupalikatole View Post
pls help me with answers.. exam in a week

1. Role of IkB in NFkB signal transduction pathway from IL1 binding to IL6induction? Its not phosphorylation of NFkB

2. Michelis constant for guanine

3. TGFb traetment causes decrease in no. of normal cells but tumor cells remain unchanged.. mutation of? i thought of APC gene as the q's was on colon cancer and marked tumor progression but its incorrect...

4. point tenderness between abductor pollicis longus and extensor pollicis brevis?

5. diabetic peripheral neuropathy pain type?

6. 2 month old with ABO mismatch plus neutropenia and lymphocytosis... not Congenital CMV..

7. correlation coefficient r= -0.25 between body fat and TLC

8. SLE women with hematologic abnormality... i thought increased ESR but not rouleaux formation ..

9. 6 yr kid with macrorchidism and tanner stage 2 of pubic and axillary hair... height percentile? i thought the q's was on fragile X?

10. bone marrow in 47XY+21 with pancytopenia lethargy bruises pallor fever

11. resistance to protease inhibitor

12. in lysosomal storage disease.. mechanisms of lysosomal enzyme finding? its not degradation of enzymes in cytoplasm

13. histo slide of GE junction . not CMV... i think it will be H.Pylori then

14. shock q's? not cardiogenic not anaphylactic.. i think it will be hypovolemic
1. When IkB is phosphorylated, it get's off NFkB and NFkB goes to nucleus, binds DNA and causes DNA transcription. At the same time it induces IkB transcription, and is in turn again inactivated.
4. Correct answer is scaphoid bone fracture and its avascular necrosis, because scaphoid bone has poor vascularisation
5. Burning
7. Thrombocytopenia, caused by immunologic mechanisms
9. 75th percentile after one year, 25th later, because due to precocious puberty child will at first grow faster, but will later be shorter (due to epiphyseal fusion)
10. It should be acute lymphoblastic leukemia
12. abnormal trafficking of enzymes (no mannose-6-phosphate on their surface)
14. Cardiogenic

I can't recall other answers or didn't know them.
What was your answer about that girl with MAC, lymphadenopathy and absent granulomas?
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Old 07-12-2014
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6. Congenital Neutropenia

According to FA 2013 (pg. 344), the WBC differential from highest to lowest (per USMLE):
Neutrophils (54-62%) [This patient has 5% at the age of 1 month]

I put down Congenital CMV infection (it was wrong). This is my next best answer.
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Old 04-03-2015
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Default question4

point tenderness in the area of snuff box hints to the scaphoid fracture.
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Old 09-26-2015
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7. correlation coefficient r= -0.25: IF rnear to 1 that means there is a correlation. if r is near to zero that means there is no correlation and plus means there is positive correlation and minus means there is negative correlation. So there is weak negative correlation, that means when one of the parameters increases another decreases.

8. SLE women with hematologic abnormality... SLE causes to pancytopenia - so anemia, trombocytppenia and neutropenia is possible
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