Mechanism of Drug treatment in Nephrogenic Diabetes Insipidus? - USMLE Forums
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Old 07-03-2013
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Drug Mechanism of Drug treatment in Nephrogenic Diabetes Insipidus?

why are thiazides, amiloride and indomethacin given for patients with nephrogenic DI?
can anyone please help me with the mechanism of these drugs in treating DI?
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Old 07-03-2013
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thiazide decrease ecf volume which lead to increase sodium and water reabsorption from pct
amiloride antagonize the effect of lithim on collecting duct
also same effect as thiazide
indomethacin inhibit pg in kidney so decrease renal flow( decrease polyuria)
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Old 07-04-2013
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Treatment for nephrogenic diabetes insipidus?

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Pharmacology-, Renal-

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