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Old 07-04-2013
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Question Blood/Gas Coefficient of Anesthetic Agent

Hi i want to know that how:

1) more soluble the anesthetic in blood, slower the anesthesia
2) anesthesia with low blood gas ratio have fast onset and recovery
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Old 07-06-2013
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Guys u r preparing for usmle .u should knoe the answer :-P
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Old 07-06-2013
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Quote:
Originally Posted by medicalbiology View Post
Hi i want to know that how:

1) more soluble the anesthetic in blood, slower the anesthesia
2) anesthesia with low blood gas ratio have fast onset and recovery
The anesthetic will act only when its partial pressures equalize in all compartments ... A gas thats more soluble will take longer to equalise and hence longer time till onset.

A gas with low blood gas coefficent is not soluble in blood so the partial pressures becomes equal faster hence faster onset...
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Old 07-06-2013
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Blood/gas ratio and blood/partition coefficient are two different things.
Blood/gas ratio is ratio between protein bound anesthetic and partial pressure of this anesthetic in blood. Hence, lower the blood/gas ratio- more of the gas dissolved in blood and quicker the effect.
Blood/gas partition coefficient refers to solubility of a gas in blood. Higher the ratio- greater the solubility and vice versa. And if the gas isn't soluble, when it reaches brain, it has higher concentration for achieving desired effect.
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