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Old 07-06-2013
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Biochemistry Ammonia Stops TCA Cycle!

how can increase in ammonia levels stops TCA cycle ?? its mentioned in fa pg 107
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Old 07-06-2013
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Through depletion of alpha-ketoglutarate.
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Old 07-07-2013
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Quote:
Originally Posted by gamx View Post
through depletion of alpha-ketoglutarate.
plz explain
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Old 07-07-2013
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look at page 106. end of the page it shows how alpha-ketoglutarate used for producing urea in liver, therefore whenever liver is overworking making urea, alpha-ketoglutarate would be depleted and because it is needed for TCA cycle, lacking of alpha-ketoglutarate would inhibits the TCA cycle.
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