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Old 07-08-2013
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Angry how n why mitochondrial damage can cause incomplete reduction of oxygen?

I am really having hard time to understand how reperfusion injury cause cell damage. I understand its due to more production ROS, reactive oxygen species. And the free radicals are produced in reperfused tissue as a result of mitochondrial damage, causing incomplete reduction of oxygen that is coming to cell.(Robbins and Cotran 8e, Page 24; Rapid Review 3e, Page 07). I just know it but i dont know how. Would someone PLEASE explain a bit more elaborately how mitochondrial damage can cause incomplete reduction of oxygen at first place?? I am desperatly looking for the answer but i didnt find it explained in any textbooks i read. Kindly help.
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