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Old 07-16-2013
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Drug Sodium channel blocker and action potential

why in firstaid the class 1 decrease slope of repolarization slope3 what is the mechanism?
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Old 07-16-2013
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I think class 1a antiarrhytmics like disopyramide and procainamide, slow repolarization by inhibiting potassium efflux which is similar to the mechanism of action of amiodarone and other class 3 antiarrhytmics.
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Old 07-16-2013
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Quote:
Originally Posted by cage92 View Post
why in firstaid the class 1 decrease slope of repolarization slope3 what is the mechanism?
To be more concrete Class I antiarrhythmics (all - Ia, Ib and Ic) decrease slope of phase 0 ( Ina)
As for Class IA it also blocks K+ channel (as class III) decreasing slope of phase 3 ( along with decreasing phase 0 as all other class I antiarrhythmic )
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Old 07-16-2013
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guys thanks for the explanationn
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