General question about Tardive Dyskinesia and DA - USMLE Forums
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Old 07-23-2013
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Default General question about Tardive Dyskinesia and DA

I understand the general concept, that when you decrease Neurotransmission (eg, dec NE release), you will up regulate the number of adrenergic receptors on post synaptic neurons.

But in the pharmacology videos, Lionel Raymon says "increasing DA neurotransmission will upregulate the number of DA receptors on synaptic cells". (in the context of extrapyramidal symptoms going from acute to chronic)

I don't understand how both DEC and INC neurotransmission can both cause an upregulation of Receptors on post synaptic cells.
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Old 07-23-2013
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Actually nevermind. Decreasing Neurotransmission can result in the same effect as blocking the receptors that those transmitters should act on (DA Antagonists)

So in either situation, would see the same effect of upregulation.

I got tripped up, because in the vidoes, he said that it was the increase DA release which caused the upregulation. Perhaps he meant blocking those DA receptors would cause the sensitization (akathesia), which would then progress to Tardive Dyskinesia, if those already sensitive receptors continuously get blocked (because of the upregulation).
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