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Old 07-26-2013
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Question why normal PTH in hypoalbuminemia

why normal PTH in hypoalbuminemia?
I think PTH should be decreased because low albumin levels attach less calcium so more free calcium is present which should decrease PTH.
SOURCE:goljan 3rd ed. pg 493(diagram 22-15)
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Old 07-26-2013
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Hypoalbuminemia only affects the total calcium levels. The ionized calcium levels remain the same. And its the level of the ionized calcium that influences PTH output.
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exactly. bound calcium should be reduced but free calcium remains the same. pth only has a negative feedback with free calcium, not bound calcium.
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the above
two posts are correct!
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Quote:
Originally Posted by rohit39 View Post
Hypoalbuminemia only affects the total calcium levels. The ionized calcium levels remain the same. And its the level of the ionized calcium that influences PTH output.
yes exactly
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