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Old 07-29-2013
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Default glucagon on KB metabolism?

Kaplan physiology lecture saying glucagon inc KB metabolism

Strictly speaking, which step?

lipolysis under cortisol, catecholamine to make FA CoA-> acetyl-CoA

FA-CoA to Acetyl-CoA is not hormone regulated.

Acetyl-CoA go gluconeogenesis this is affect by glucagon.

Acetyl-CoA go KB metabolism by transport and further steps.

didnt find any exact step affected by glucagon
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Old 08-01-2013
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Theoretically glucagon increases lypolysis which should increase dramatically acetyl-CoA which increases KB production, but in fact glucagon doesn't affect lypolisis in humans so it shouldn't increase KB. Glucagon decreases the amount of malonylo-CoA which activates Carnityhyne acyl transpherase I which allows more fatty acids to enter mitochondrium and finally decreasing oxaloacetate which goes to gluconeogenesis makes Krebs cycle less effective thus making A-CoA go to KB.
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