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Old 07-31-2013
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Immunology Why Low C3 Levels!

Hey guys,
why is c3 level low in certain diseases, such as rheumatoid arthritis, type III hypersensitivity?
can any of you tell me all the possible diseases and the mechanisms of decreased C3?

really appreciate it! :sorry:
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Old 07-31-2013
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It gets deposited in tissues with immunocomplex ds. Thats why the plasma level is low
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Old 07-31-2013
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RA starts as a type III hypersensitivity, so you can add it to the type III category. C3 is decreased because the immune complexes that settle in tissues over activate the complement pathway and recruit immune cells, which C3 mediates multiple reactions thus consumed.
Hope this helps
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Old 08-10-2013
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Remmeber , IGM, IGG that activate the complement through the c3 , in type 3 hypersensitivity igG recognize a soluble antigen , bind to it, form a comlex then the c3 bind , ... In this way they get hypo complement
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Old 08-10-2013
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She Said Sally Cooked a Poison Marconi



SlE
SBE
Shunt
Cryoglobunemia
PSGN
MPGN
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