Urinary 17-OH steroids VS 24hr urine free cortisol - USMLE Forums
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Old 08-02-2013
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Default Urinary 17-OH steroids VS 24hr urine free cortisol

Kaplan lecture notes states that in the past, 'Urinary 17-OH steroids' were used as an index of Cortisol Secretion. [/i]I understand this to be any 17-OH steroid that gets metabolized (glucuronidated) in the Liver, and then excreted in Urine, which is what gets measured.[/i] Is this correct?

It then states that the above method, is replaced by measuring '24-hour urine-free cortisol'.

I understand that it's more specific for 'cortisol' that is being measured here. I assume we are still talking about inactive, glucuronidated metabolites of cortisol...but what does "24 hour URINE FREE" mean?
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Old 08-02-2013
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nvm, free cortisol is free because it's not glucuronidated. and xs cortisol will not be able to bind Corticosterone Binding Protein, and gets peed out. makes sense.
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