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Old 08-20-2013
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Question Why hypocalcemia in Alkalosis!

Can someone explain the mechanism of hypocalcaemia in Alkalosis and whether it causes tetany or not and what happens to level of calcium in acidosis?
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Old 08-20-2013
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Alkalosis means less acids in the blood. These acids usually compete with Calcium in binding to albumin. If they are depleted then Calcium will have more room to bind to albumin and therefore less free Calcium.

The reverse is true in the case of acidosis.

This issue was discussed before here
Alkalosis and Tetany
and here
Cause of hypocalcemia tetany

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Old 08-21-2013
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Hi there,

In cases of alkalosis, we typically see hypocalcemia because as the blood's pH rises (low H+), which results in an ionization of albumin, making in more negative. As a result, calcium binds to albumin with greater affinity, and this reduces the free calcium. As a result, we see hypocalemia. If severe enough you will see signs such as Chvostek's sign, hyperactive tendon reflexes, carpopedal spasm, etc, etc, etc.

The opposite may be seen in cases of acidosis.
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Old 08-21-2013
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Quote:
Originally Posted by USMLE-Success-Academy View Post
Hi there,

In cases of alkalosis, we typically see hypocalcemia because as the blood's pH rises (low H+), which results in an ionization of albumin, making in more negative. As a result, calcium binds to albumin with greater affinity, and this reduces the free calcium. As a result, we see hypocalemia. If severe enough you will see signs such as Chvostek's sign, hyperactive tendon reflexes, carpopedal spasm, etc, etc, etc.

The opposite may be seen in cases of acidosis.
thanks, appreciate it
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Old 08-21-2013
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Quote:
Originally Posted by Sabio View Post
Alkalosis means less acids in the blood. These acids usually compete with Calcium in binding to albumin. If they are depleted then Calcium will have more room to bind to albumin and therefore less free Calcium.

The reverse is true in the case of acidosis.

This issue was discussed before here
Alkalosis and Tetany
and here
Cause of hypocalcemia tetany

-
thanks, appreciate it
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Acid-Base-, Electrolytes-, Physiology-

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