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Old 11-16-2010
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Question ALA Dehydratase or ALA Synthase

In firstaid 2010 page 348:
lead poisoning enzyme affected is "ALA dehydratase"
BUT
In errata FA (from firstaid website) it says replace it with " ALA synthase "
which one is correct plz clarify , thanks
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Old 11-16-2010
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Lead denatures Ferrochelatase (Heme synthase), ALA Dehydrase and Ribonuclease.
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Old 11-16-2010
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lead poisoning inhibits ALA dehydrase & ferrochelatase in heme synthesis.
vit B6 deficiency effects on ALA synthase...
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Old 11-16-2010
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The hemoglobin pathway has been excellently demonstrated with cilinical correlation by our staff Sabio here's the link
Heme synthesis and porphyria diagram
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Old 11-16-2010
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Lead poisoning directly inhibits ALA dehydratase and ferrochelatase. Lead poisoning can cause sideroblastic anemia which inhibits ALA synthase.

So in short, lead poisoning inhibits ALA dehydratase directly and ALA synthase indirectly.
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Biochemistry-, Hematology-, Toxicology-

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