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Old 08-26-2013
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Question Alkalosis and Hypokalemia

How alkalosis cuz hypokalemia?
if this is due to H and K pump then it means more H moves outside cell and K moves inside cell..So it should be Acidosis cuz more H in ECF is acidosis as like increase K in ECF is hYperkalemia.
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Old 08-31-2013
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Strictly speaking, It's not alkalosis that causes hypokalemia. It's the reverse, hypokalemia causes alkalosis. However, let's discuss the two directions below:

How does Hypokalemia causes Metabolic Alkalosis?
Hypokalemia causes potassium to move from cells into the extracellular fluid, and this transcellular potassium flux is accompanied by movement of hydrogen ions from the extracellular fluid into cells to maintain electroneutrality. The movement of hydrogen into the cells increases the plasma bicarbonate concentration and simultaneously lowers the intracellular pH. The ensuing intracellular acidosis in renal tubular cells promotes hydrogen secretion and therefore bicarbonate reabsorption.

How does Metabolic Alkalosis causes Hypokalemia?
Alkalosis per se does not cause hypokalemia. However, hypokalemia can co-exist with alkalosis because they have the same causation. The major causes of metabolic alkalosis (vomiting, diuretics, mineralocorticoid excess) directly induce renal potassium loss.


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Old 08-31-2013
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Great explanation StepTaker, also when the HCO3 is Reabsorb in the renal tube, it mandate to excrete the K as an obligate Cation ( K ) so make it to lower his level even more.

UW give a great explanation as well of this condition.

Causes of Hypokalemia that i found a little tricky on the exam "Insulin, B-Agonist and Alkalosis as well"...

Keep that in mind!
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