Alkalosis and Hypokalemia - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

Thread Tools Search this Thread Display Modes
Old 08-26-2013
medicalbiology's Avatar
USMLE Forums Guru
Steps History: Not yet
Posts: 394
Threads: 128
Thanked 108 Times in 88 Posts
Reputation: 118
Question Alkalosis and Hypokalemia

How alkalosis cuz hypokalemia?
if this is due to H and K pump then it means more H moves outside cell and K moves inside cell..So it should be Acidosis cuz more H in ECF is acidosis as like increase K in ECF is hYperkalemia.
Reply With Quote Quick reply to this message

Old 08-31-2013
USMLE Forums Master
Steps History: 1+CK+CS+3
Posts: 3,263
Threads: 147
Thanked 4,956 Times in 1,563 Posts
Reputation: 5052

Strictly speaking, It's not alkalosis that causes hypokalemia. It's the reverse, hypokalemia causes alkalosis. However, let's discuss the two directions below:

How does Hypokalemia causes Metabolic Alkalosis?
Hypokalemia causes potassium to move from cells into the extracellular fluid, and this transcellular potassium flux is accompanied by movement of hydrogen ions from the extracellular fluid into cells to maintain electroneutrality. The movement of hydrogen into the cells increases the plasma bicarbonate concentration and simultaneously lowers the intracellular pH. The ensuing intracellular acidosis in renal tubular cells promotes hydrogen secretion and therefore bicarbonate reabsorption.

How does Metabolic Alkalosis causes Hypokalemia?
Alkalosis per se does not cause hypokalemia. However, hypokalemia can co-exist with alkalosis because they have the same causation. The major causes of metabolic alkalosis (vomiting, diuretics, mineralocorticoid excess) directly induce renal potassium loss.

Reply With Quote Quick reply to this message
The above post was thanked by:
medicalbiology (08-31-2013), rulz (08-31-2013), thind (08-31-2013)
Old 08-31-2013
USMLE Forums Master
Steps History: Step 1 Only
Posts: 576
Threads: 25
Thanked 522 Times in 263 Posts
Reputation: 532

Great explanation StepTaker, also when the HCO3 is Reabsorb in the renal tube, it mandate to excrete the K as an obligate Cation ( K ) so make it to lower his level even more.

UW give a great explanation as well of this condition.

Causes of Hypokalemia that i found a little tricky on the exam "Insulin, B-Agonist and Alkalosis as well"...

Keep that in mind!
Nothing is Impossible, the Word Itself says "I'm Possible"
Reply With Quote Quick reply to this message


Acid-Base-, Electrolytes-

Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
DKA & Hypokalemia gear2d USMLE Step 2 CK Forum 3 09-18-2016 05:28 AM
ASA causes hyperkalemia or hypokalemia ? tyagee USMLE Step 2 CK Forum 5 07-07-2013 12:57 PM
Hypokalemia step_enhancer USMLE Step 2 CK Forum 12 09-06-2012 12:02 AM
Resp. alkalosis/metabolic alkalosis mohitkmc USMLE Step 1 Forum 4 12-27-2011 09:46 AM
Why Hypokalemia with Diuretics? indigo USMLE Step 1 Forum 6 12-11-2011 07:50 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2016 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)