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Old 08-27-2013
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RBC How does G6PD Deficiency Cause Gout!

How in the world does G6PD deficiency lead to gout?? I read on here that someone wrote it activates the HMP shunt; which is false since G6PD is required for that shunt and hence you don't make Ribose5phosphate. So how does it do it??
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Old 08-27-2013
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That's beyond low Yield but to answer your question. G6PD causes gout when the frequency of hemolytic attacks is high. Increased cell turnover causes the increased Uric acid production, which the hyperurecemia is the hallmark of gout.
To sum it up, someone with gout from G6PD deficiency must have had been suffering from frequent attacks for a while.
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Old 08-27-2013
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I understand that it is probably extremely low yield fact, just something that piqued my interest. So essentially, the intravascular hemolysis via G6PD deficiency leads to inc cell turnover by hence the inc in NT synth and Uric acid accumulation aka an "overproducer" if you will.

Thanks for the insight Mo-tongji, what year are you?
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Quote:
Thanks for the insight Mo-tongji, what year are you?
I'm in my internship, graduating next year.
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Old 08-30-2013
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the better reason given in kaplan is:
g6pd def leads to accumulation of G6P, the synthesis of which requires Phosphate, which gets depleted and hence less AMP can be converted to ATP.... thus AMP accumulates. Now this AMP is converted to uric acid through purine cataboloism.
Read KLN chapter on purines at the end of the biochem section... in fact gout is also seen in fructosuria and galactosemia due to the same reason
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