Urine Osmolarity in Primary Polydipsia - USMLE Forums
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Old 09-11-2013
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Urine Sample Urine Osmolarity in Primary Polydipsia

If we drink a lot of water then urine osmolality should decrease but in primary polydipsia it increases...how??
In diabetes inspidus osmolality decrease which makes sense.
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Old 09-11-2013
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Can you quote where you have read this ???

Primary polydypsia should manifest like this
  • plasma osmolarity = low to normal
  • urine osmolarity = low

while DI should manifest like this
  • plasma osmolarity = high
  • urine osmolarity = low
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Old 09-11-2013
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Oh sorry gradual increase in osmolality is due to water depriviation test.
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that is logical i think because in polydypsia the urine osm is due to excess water intake not due to a defect in ADH system ....so water deprivation should increase urine Osm to counteract the increasing plasma osm by conserving water through ADH system....
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Old 09-12-2013
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in primary polydipsia drinking too much water decrease plasma osmalarity this will leads to decrease secretion of ADH, so body doesnt conserve water and will lead to dilute urine.. correct me if i am wrong...
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Old 09-12-2013
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Npktun!
Thanks for saving the mess. I have been thinking about the post becos I know it doesn't make sense for primary polydypsia to result in increased urine osmolarity.
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