ACE Inhibitors effects on Aldosterone Renin and Bradykinin - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 11-21-2010
mtoi's Avatar
USMLE Forums Scout
 
Steps History: Not yet
Posts: 71
Threads: 30
Thanked 52 Times in 29 Posts
Reputation: 62
Drug ACE Inhibitors effects on Aldosterone Renin and Bradykinin

explain the effect [decrease/ increase/ no change] of angiotensin-converting-enzyme inhibitor on aldosterone, renin and bradykinin
__________________
i'm lukng 4 STUDY BUDDY, search 'mtoi' on facebook
Reply With Quote Quick reply to this message



  #2  
Old 11-21-2010
hedihav_x's Avatar
USMLE Forums Scout
 
Steps History: 1+CK+CS
Posts: 60
Threads: 10
Thanked 52 Times in 21 Posts
Reputation: 62
Default

ACEIs will decrease aldosterone,increase renin & increase bradykinin
Reply With Quote Quick reply to this message
The above post was thanked by:
mtoi (11-22-2010)
  #3  
Old 11-22-2010
mtoi's Avatar
USMLE Forums Scout
 
Steps History: Not yet
Posts: 71
Threads: 30
Thanked 52 Times in 29 Posts
Reputation: 62
Default

perfect
i understand decrease in aldo and increase in bradykinin, but not increase in renin. please explain

decrease in aldo is therapeutic effect for decreasing blood pressure
increase in bradykinin is side effect causing cough and angioedema
__________________
i'm lukng 4 STUDY BUDDY, search 'mtoi' on facebook
Reply With Quote Quick reply to this message
  #4  
Old 11-22-2010
USMLE Forums Guru
 
Steps History: 1 + CK
Posts: 373
Threads: 30
Thanked 374 Times in 160 Posts
Reputation: 384
Default

Quote:
Originally Posted by mtoi View Post
perfect
i understand decrease in aldo and increase in bradykinin, but not increase in renin. please explain

decrease in aldo is therapeutic effect for decreasing blood pressure
increase in bradykinin is side effect causing cough and angioedema
Just for recap...

Renin is released from kidney in response to
  • sympathetic stimulation(via β1-receptors)
  • renal artery hypotension
  • decreased sodium delivery to the distal tubules of the kidney.
Renin is a proteolytic enzyme which converts circulating angiotensinogen to Angiotensin 1, which is converted by ACE to Angiotensin 2.

So, by blocking ACE..... the level of Renin, Angiotensin 1 & Bradykinin should increase and the level of Angiotensin 2 & Aldosterone should fall.
__________________
Knowing is not enough; we must apply.
Willing is not enough; we must do.
Reply With Quote Quick reply to this message
The above post was thanked by:
awaisnaeem86 (11-22-2010), mtoi (11-23-2010)
  #5  
Old 11-22-2010
USMLE Forums Addict
 
Steps History: 1+CK+CS
Posts: 167
Threads: 8
Thanked 134 Times in 47 Posts
Reputation: 144
Default

Renin is released from kidney in response to
sympathetic stimulation(via β1-receptors)
renal artery hypotension
decreased sodium delivery to the distal tubules of the kidney.
Renin is a proteolytic enzyme which converts circulating angiotensinogen to Angiotensin 1, which is converted by ACE to Angiotensin 2.

So, by blocking ACE..... the level of Renin, Angiotensin 1 & Bradykinin should increase and the level of Angiotensin 2 & Aldosterone should fall.

and also loss of negative feedback of angiotensin 2 on AT receptor located on kidney. so increase in renin and angiotensin 1.
Reply With Quote Quick reply to this message
The above post was thanked by:
mtoi (11-23-2010)



Reply

Tags
Pharmacology-, Physiology-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Beta and Alpha Receptors effects on Insulin and Renin rasheed USMLE Step 1 Mnemonics 6 11-23-2015 03:37 AM
Is memorizing First Aid enough to ace Step I? heights USMLE Step 1 Forum 12 06-05-2012 09:21 PM
Cell Wall Inhibitors anoop_1198 USMLE Step 1 Forum 1 07-28-2010 08:30 PM
Mnemonic RiRi to remember Alpha and Beta receptor effects on Insulin and Renin raheel_memon USMLE Step 1 Mnemonics 1 07-22-2010 05:17 PM
Differentiating Aldosterone Adenoma from Idiopathic Hyperaldosteronism rasheed USMLE Step 2 CK Bits & Pieces 0 05-06-2010 09:53 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)