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Old 09-21-2013
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Virus infectious mononucleosis

Even tho EBV infects B cell,why does T cell hyperplasia occur in LN and sleen resulting in splenomegaly and lymphadenopathy respectively? pathogenesis plz!
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Old 09-22-2013
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Correct Answer EBV and T-Cells

EBV turns on the oncogenes within B-Cells, leading to a perpetual activation of pathways of B-Cell proliferation and anti-apoptosis. Now, as you know that body's response to a virally infected cell is chiefly a cell mediated response and to control such a high number of cells with infective virion inside them, we need an equally large army of T-Cells and hence the hyperplasia in nodal paracortex and splenic PALS.

Feel free to ask if I am not being clear enough.
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