Why leoprolide as GnRH supressor - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 09-24-2013
medicalbiology's Avatar
USMLE Forums Guru
 
Steps History: Not yet
Posts: 394
Threads: 128
Thanked 108 Times in 88 Posts
Reputation: 118
Drug Why leoprolide as GnRH supressor

It is actually GnRH analog BUT why it is used for precocious puberty.
UW said its continuous infusion supress GnRH.
Reply With Quote Quick reply to this message



  #2  
Old 09-24-2013
USMLE Forums Scout
 
Steps History: Not yet
Posts: 35
Threads: 8
Thanked 8 Times in 8 Posts
Reputation: 18
Default Leuprolide

Ok in normal physiological doses GnRH is secreted in a PULSATILE fashion. Such as in the case of precocious puberty its a pulsatile secretion. If we GIVE it in a CONTINUOUS infusion it will lead to inhibition of secretion. The reason for this is because of DOWNREGULATION of receptors because of constant stimulation. So yeah sorry didnt finish the whole explanation WE STOP precocious puberty from happening if we give it in a continuous fashion.

Again anyone please feel to correct me if I am wrong.
Reply With Quote Quick reply to this message
  #3  
Old 09-24-2013
USMLE Forums Scout
 
Steps History: Not yet
Posts: 35
Threads: 8
Thanked 8 Times in 8 Posts
Reputation: 18
Default

Please answer my question.
Reply With Quote Quick reply to this message
 
  #4  
Old 09-24-2013
medicalbiology's Avatar
USMLE Forums Guru
 
Steps History: Not yet
Posts: 394
Threads: 128
Thanked 108 Times in 88 Posts
Reputation: 118
Default

Yup i think u r ryt i forgot that PULSTILE thing..
Reply With Quote Quick reply to this message



Reply

Tags
Endocrine-, Pharmacology-, Physiology-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
The mecahnims of GnRH in precocious puberty! aghammoud85 USMLE Step 2 CK Forum 2 08-11-2011 05:41 PM
Confusion about Flutamide and GnRH medico.in USMLE Step 1 Forum 3 02-28-2011 05:04 PM
Continuous GnRH Yallah USMLE Step 1 Forum 7 11-01-2010 01:40 AM
question - GnRH analog mtoi USMLE Step 1 Forum 2 10-31-2010 09:41 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)