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Old 10-07-2013
medicalbiology's Avatar
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Kidney Renal regulation to Hypoxia!

According to uworld renin is regulated by 3 mechanisms:
Macula densa
intra renal baroreceptor
Beta adrenergic

So does this mean ther is no renal regulation to HYPOXIA ????
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Old 10-07-2013
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Macula densa is what senses hypoxia and signals JG cells to secrete Renin.
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Old 10-08-2013
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I read somewhere that macula densa sense Nacl .... B-)
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Old 10-08-2013
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Decreasing the Renal Blood flow causes a decrease in GFR which gives more time for PCT to reabsorb NaCl , thus we have less NaCl reaching to the Macula Densa. Macula Densa causes the release of Renin in response.

Increasing the Renal Blood flow causes an increase in GFR which gives less time to PCT for reabsorbing NaCl , thus more NaCl reaching the Macula Densa and less Renin production.

So although Macula Densa responses to NaCl , it is also in a way linked to Blood flow to the kidney.

Hope that helps.
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Old 10-08-2013
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in response to hypoxia erythropoietin is made from cell surrounding the peritubular capillaries

so i think there is some other mechanism not involving macula densa that regulated EPO production in response to hypoxia form peritubular capillaries
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Old 10-08-2013
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U mean hypoxia--->renal vasodilation---->increase gfr--->more Na reaches JG apparatus--->so increase production of renin.

P.S renal vasodilator increase gfr ryt??

Anwar ur answer seems ryt
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