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Old 10-08-2013
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Kidney tubular fluid/plasma ultrafiltrate(TF/PF)

1) According to uworld tubular fluid/plasma ultrafiltrate of inulin , creatine increase in proximal tubule and the reason is water is absorbed faster then them...i mean if we talk about PAH its Tf/PF increases because of secretion...BUT inulin is not secreted so how its tubular concentration increase more then its filtration....

2) how water increase tubular fluid of inulin more then its filtration amount
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Old 10-08-2013
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Originally Posted by medicalbiology View Post
1) According to uworld tubular fluid/plasma ultrafiltrate of inulin , creatine increase in proximal tubule and the reason is water is absorbed faster then them...i mean if we talk about PAH its Tf/PF increases because of secretion...BUT inulin is not secreted so how its tubular concentration increase more then its filtration....

2) how water increase tubular fluid of inulin more then its filtration amount
1&2)As we move forward in proximal tubule water absorbs but inulin doesnt,,,so in remaining water(TF) conc of inulin is higher than that of plasma(PF).

hope u understand.
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Old 10-08-2013
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as you move along the proximal tubule water keeps getting absorbed but inulin doesnt. The total amount of inulin doesnt change but its CONCENTRATION increases. Hope that helps.
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Old 10-08-2013
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Remember that point about how Inulin is neither secreted, nor reabsorbed...this is what they mean. Inulin concentration increases (because the water is getting reabsorbed), but its actual amount stays the same. This is why Inulin can be used to estimate GFR.
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as you move across the from the proximal tubule water is getting reabsorbed but not inulin....so inulin conc increases progressively as water is being absorbed....
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Old 10-09-2013
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Hmmm your post show that ther is difference between concentration and amount....
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