Mirtazepine toxicity - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 10-08-2013
USMLE Forums Scout
 
Steps History: Not yet
Posts: 13
Threads: 5
Thanked 3 Times in 3 Posts
Reputation: 13
Drug Mirtazepine toxicity

Im trying to understand why the toxicity of mirtazepine is sedation, increased appetite and serum cholesterol. Activation of the alpha 2 receptor causes decreased sympathetic outflow and decreased insulin release, so if you blocked it with mitrazapine, wouldn't you increase the sympathetic outflow which is the opposite of sedation? Why do serum cholesterol and appetite increase? Thanks
Reply With Quote Quick reply to this message



  #2  
Old 10-08-2013
USMLE Forums Scout
 
Steps History: Step 1 Only
Posts: 18
Threads: 6
Thanked 3 Times in 3 Posts
Reputation: 13
Default

same applies to clonidine causing sedation
Reply With Quote Quick reply to this message
  #3  
Old 10-08-2013
USMLE Forums Scout
 
Steps History: Not yet
Posts: 13
Threads: 5
Thanked 3 Times in 3 Posts
Reputation: 13
Default

Interesting but I don't see how block the alpha 2 receptor causes sedation? Clonidine activates it, thus decreasing sympathetic outflow
Reply With Quote Quick reply to this message
 
  #4  
Old 10-08-2013
USMLE Forums Scout
 
Steps History: Step 1 Only
Posts: 18
Threads: 6
Thanked 3 Times in 3 Posts
Reputation: 13
Default

I wish I know. Maybe it has some intrinsic agonist activity. Kinda crappy explanation.
Reply With Quote Quick reply to this message
  #5  
Old 10-10-2013
USMLE Forums Master
 
Steps History: 1+CK+CS
Posts: 1,867
Threads: 149
Thanked 2,104 Times in 1,049 Posts
Reputation: 2124
Default

Quote:
Originally Posted by dandaman486 View Post
Im trying to understand why the toxicity of mirtazepine is sedation, increased appetite and serum cholesterol. Activation of the alpha 2 receptor causes decreased sympathetic outflow and decreased insulin release, so if you blocked it with mitrazapine, wouldn't you increase the sympathetic outflow which is the opposite of sedation? Why do serum cholesterol and appetite increase? Thanks
Mirtazapine causes sedation because it blocks the histaminergic (H1) receptor. In contrast to the H1 receptor, mirtazapine has very low affinity for the mACh receptors, and thus is virtually devoid of any anticholinergic properties at clinical doses.
That is why it is a drug of choice in depressed patients with significant anxiety or insomnia with loss of appetite/wt.
__________________
A man doesn't know what he knows until he knows what he doesn't know.
“What is man? He's just a collection of chemicals with delusions of grandeur.”
Reply With Quote Quick reply to this message



Reply

Tags
Pharmacology-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Digoxin Toxicity Ahmed mido USMLE Step 1 Forum 5 06-25-2016 08:44 PM
cause of Lithium toxicity stfidel USMLE Step 2 CK Forum 3 03-05-2013 01:38 PM
Drug Toxicity koyi USMLE Step 1 Forum 11 01-31-2013 07:41 AM
Amiodarone toxicity anomali USMLE Step 1 Forum 11 05-01-2012 09:36 AM
TCA toxicity abhinav USMLE Step 1 Forum 2 03-27-2010 04:38 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)