Step 1 practice Qnz - 8 - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 11-30-2010
USMLE Forums Guru
 
Steps History: Step 1 Only
Posts: 487
Threads: 95
Thanked 1,458 Times in 356 Posts
Reputation: 1468
Arrow Step 1 practice Qnz - 8

A 68-year-old male presents to your office with exertional thigh and leg pain and decreased sexual performance. His past medical history is significant for hypertension, diabetes mellitus and myocardial infarction experienced two years ago. He smokes two packs per day and consumes alcohol occasionally. His dorsalis pedis pulses are weak in both feet. Evaluation shows moderate peripheral arterial disease of both lower extremities. This patient experiences symptomatic improvement from a drug that dilates arteries and inhibits platelet aggregation. Which of the following drugs is most likely described in this scenario?

A. Heparin
B. Argatroban
C. Warfarin
D. tPA
E. Aspirin
F. Ticlopidine
G. Abciximab
H. Cilostazol
Reply With Quote Quick reply to this message
The above post was thanked by:
Linc (02-16-2016)



  #2  
Old 11-30-2010
USMLE Forums Addict
 
Steps History: 1 + CS
Posts: 159
Threads: 52
Thanked 71 Times in 32 Posts
Reputation: 81
Default

its cilostazol...cilostazol is a phosphodiesterase inhibitor..it decreases platelet aggregation and also causes arterial vasodilation..
its used for intermittent claudication and peripheral vascular disease..
Reply With Quote Quick reply to this message
The above post was thanked by:
aktorque (11-30-2010)
  #3  
Old 11-30-2010
USMLE Forums Guru
 
Steps History: Step 1 Only
Posts: 487
Threads: 95
Thanked 1,458 Times in 356 Posts
Reputation: 1468
Arrow

Very good Doc. You are the best Doc on board. Keep it up.
Reply With Quote Quick reply to this message
 
  #4  
Old 11-30-2010
USMLE Forums Guru
 
Steps History: Step 1 Only
Posts: 487
Threads: 95
Thanked 1,458 Times in 356 Posts
Reputation: 1468
Arrow

Full explanation for others who didn't get this Qnz

Several molecules, including thrombin, ADP, and thromboxane A2, activate platelets by acting on cell surface receptors. Interference with post receptor signaling can alter platelet functions. Agents that increase platelet cyclic AMP decrease platelet aggregation by preventing platelet shape change and granule release.

Dipyridamole and cilostazol work by decreasing the activity of platelet phosphodiesterase, the enzyme responsible for breakdown of cyclic AMP. Cilostazol, in addition to inhibition of platelet aggregation, also is a direct arterial vasodilator. Cilostazol is approved by the FDA for the treatment of intermittent claudication (peripheral arterial disease).
Reply With Quote Quick reply to this message
The above post was thanked by:
Dhakshi (10-27-2016), Linc (02-16-2016)
  #5  
Old 11-30-2010
USMLE Forums Guru
 
Steps History: 1 + CK
Posts: 373
Threads: 30
Thanked 374 Times in 160 Posts
Reputation: 384
Default

@aktorque

Thanks for the question just want to add that symptom mentioned in this question comprise the "Leriche syndrome".
__________________
Knowing is not enough; we must apply.
Willing is not enough; we must do.
Reply With Quote Quick reply to this message
The above post was thanked by:
aktorque (11-30-2010), Pixie (11-30-2010)



Reply

Tags
Pharmacology-, Step-1-Questions

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Step 1 practice Qnz - 7 aktorque USMLE Step 1 Forum 8 11-30-2010 06:28 PM
Step 1 practice Qnz - 6 aktorque USMLE Step 1 Forum 10 11-29-2010 09:15 PM
Step 1 practice Qnz - 5 aktorque USMLE Step 1 Forum 3 11-20-2010 01:00 AM
Step 1 practice Qnz - 4 aktorque USMLE Step 1 Forum 5 11-19-2010 07:39 AM
Step 1 practice Qnz - 3 aktorque USMLE Step 1 Forum 4 11-19-2010 07:24 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)