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Old 10-20-2013
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Default Carcinogenesis

Hi guys

During my study I faced a question about cancer development I couldn't answer

if any one know it .. that would be helpful


If we inject a mice with a metastatic melanoma I.v; and then the cancer developed in organs such as lung and ovaries; but didn't in liver due to prior injection with antibody directed to cell surface antigen which process is most likely affected by the antibody :

1- Homing

2- Initiation

3-Invasion

4-Motility

5-Progression

6-Promotion


I didn't found their explanation in FA or Goljan

example of each would be helpful ,, thanx
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  #2  
Old 10-20-2013
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Default

Quote:
Originally Posted by Dr. Egocentric View Post
Hi guys

During my study I faced a question about cancer development I couldn't answer

if any one know it .. that would be helpful


If we inject a mice with a metastatic melanoma I.v; and then the cancer developed in organs such as lung and ovaries; but didn't in liver due to prior injection with antibody directed to cell surface antigen which process is most likely affected by the antibody :

1- Homing

2- Initiation

3-Invasion

4-Motility

5-Progression

6-Promotion


I didn't found their explanation in FA or Goljan

example of each would be helpful ,, thanx
right answer is Homing
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2015 grad , Step1-[249], Step 2CK [253], Step 2 CS [PASS(1)] , Step 3 [235], MATCHED IM 2016
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  #3  
Old 07-06-2014
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can anyone explain the difference between all the answer choices...??

I understand that homing involves the interaction between cells surface molecules of the distal sites of metastasis with receptors/ligands of cancer cells, which may provide an explanation as to why certain cancers preferentially metastasize to specific organs( e.g.. prostate cancer cells to bone).

From what I understand, invasion is a cancer cell's ability to penetrate the ECM/BM of the organ of origin/blood vessels, which determines potential for metastasis and survival outside the organ of origin. This can be accomplished by cancer cells producing enzymes or utilizing those found in the ECM/BM of the organ/blood vessel itself ( e.g. metalloproteases ( or type iv collagenase)...the ability of the cancer cells to promote angiogenesis falls under this category as well.

ANY HELP WOULD BE APPRECIATED!!
thank you
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