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Old 12-02-2010
schiwei's Avatar
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Drug glucocorticoid - anticancer MOA

Hi,

What is the MOA of glucocorticoid in the treatment against cancer? Which is more predominantly associated with it - inhibition of connective tissue proliferation or apoptosis? Thanks so much in advance!
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Old 12-02-2010
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I think they work on cellular signaling pathway.

But again, my dear, that's not high yield at all. The USMLE will never ask you about this.
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Old 12-03-2010
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Where did you get this, if you don't mind? I didn't see cancer treatment protocols in FA or UW so I was wondering what cancers you might treat with glucocorticoids...
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Old 12-04-2010
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Quote:
Originally Posted by ashishkabir View Post
Where did you get this, if you don't mind? I didn't see cancer treatment protocols in FA or UW so I was wondering what cancers you might treat with glucocorticoids...
It is given at least in leukemias, lymphomas, myelomas and breast cancer.
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Old 12-15-2010
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so that means p53 might be involved and also the fas pathway? what other major mechanisms does it involve?
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