Why is there increased cAMP in urine in primary hyperparathroid? - USMLE Forums
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Old 12-04-2010
kundra's Avatar
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Urine Sample Why is there increased cAMP in urine in primary hyperparathroid?

Can anyone tell me explanation of why we have increased urinary cAMP levels in hyperparathyroidism?? I knew it but somehow it slipped from my mind and m unable to recall now!
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Old 12-04-2010
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The parathyroid hormone works on Gs G protein which then leads to increased levels of cAMP (as second messenger).

To reinforce the concept, remember that Pseudohypoparathyroidism is caused by a fault in the G protein receptor signaling pathway and it has decreased urinary cAMP levels

I'll tell where did you read it. You read it in Kaplan Qbank
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Old 12-04-2010
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yea i just revised it from there a moment ago!
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Cell-Biology-, Endocrine-, Molecular-Biology-

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