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Old 11-16-2013
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Drug Acetazolamde and renal stones!

Hey!

I was wondering why one of the side effects of Acetazolamide is renal stones?
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Old 11-16-2013
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Acetazolamide is a carbonic anhydrase inhibitor which can cause partial renal tubular acidosis and hypokalemia as a side effect. Alongwith renal tubular acidosis, it also causes increased excretion of calcium (hypercalciuria) and decreased excretion of citrate (hypocitraturia). So there is less citrate in urine to form a soluble complex with calcium, and hence more calcium is precipitated as insoluble salt - forming calcium phosphate stone. So one of the side-effects with acetozolamide is renal stones
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Old 11-17-2013
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Pratik,

Thank you so much!
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Old 03-02-2014
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CA inhibitors cause Alkalosis of the renal tubule because they inhibit the reabsorption of bicarbonate from the tubule. If the tubule is alkaline, then the body's ph is the opposite which will be metabolic acidosis. Acidosis means there's a lot of H+, which means the H+ will displace the calicum from albumin. so no we have albumin combined to H+, ad the calicum is free in the blood! high calcium i the blood= more calcium being excreted=more calcium being present in the kidney= renal calcium stones.
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Pathology-, Pharmacology-, Physiology-, Renal-

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