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Old 11-17-2013
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GIT Crohn's NOD2 Mutation

mutation increases NF-kb which increase cytokine production so it should produce strong response to microbes UWORLD says increase NF-kb cause inflamation causing bacteria to
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Old 11-17-2013
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NOD-2 gene's protein has a domain for recognition of peptidoglycan within bacteria. In case of mutation, NOD-2 cannot activate it's NFkB or caspase pathway rendering the organism resistant and hence the microbial survival and widespread local proliferation. This however, leads to exaggerated NOD2-independant cytokine/NFkB pathways to kill those very microbe resulting in an overwhelming cytokine release and autoimmunity.
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The above post was thanked by:
nethuja (11-17-2013)


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