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Cocaine induced angina ?

3K views 4 replies 3 participants last post by  Neuron 
#1 ·
Type of angina in cocaine intake is STABLE or Prinzmetal's angina ?
Can anyone explain the mechanism behind it ?
 
#2 ·
Prinzemetal.

Mechanism: Prinzemetal agina is due to vasospastic coronary arteries. Think of a patient with Asthma. they have hyperactive bronchial smooth muscles...so you contraindicate beta-blockers as that would exacerbate the situation. Well same thing here. You have hyperactive vasopastic coronary arteries, so anything that increases cathecholamines (cocaine) would exacerbate Prinzemetal's Angina.
 
#5 ·
This is true because cocaine causes hypertension and thus the chronic exposure can, indirectly, promotes the development of a plaque.
However, always consider the age of the patient. A young patient wt an acute exposure it is plausible to be a variant angine. Otherwise if it is a middle age pt wt a note cv risk factors history, it could be an organic angina.
 
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