Thymus associations? - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

Thread Tools Search this Thread Display Modes
Old 12-11-2010
USMLE Forums Scout
Steps History: ---
Posts: 26
Threads: 17
Thanked 13 Times in 7 Posts
Reputation: 23
Question Thymus associations?

- Follicular B cell hyperplasia of thymus associated with myasthenia
- Thymoma associated with lambert eaton syndrome

Is this correct?
Reply With Quote Quick reply to this message

Old 12-13-2010
USMLE Forums Guru
Steps History: Step 1 Only
Posts: 487
Threads: 95
Thanked 1,451 Times in 356 Posts
Reputation: 1461

yes you are correct but there are more diseases associated with thymoma.
Reply With Quote Quick reply to this message
Old 12-13-2010
USMLE Forums Guru
Steps History: Step 1 Only
Posts: 487
Threads: 95
Thanked 1,451 Times in 356 Posts
Reputation: 1461

Myasthenia gravis

As many as 50% of patients with thymoma have MG, and approximately 15% of patients with MG have thymoma.4 MG is caused by autoantibodies to postsynaptic nicotinic acetylcholine receptors (anti-AChRs) at the neuromuscular junction, causing weakness of skeletal muscles. Some patients with thymoma-associated MG have an inflammatory myopathy of striated and cardiac muscles. Cardiac myositis may cause heart failure, cardiac arrhythmia, and sudden death.

Lambert-Eaton myasthenic syndrome

Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease characterized by reduced quantal release of acetylcholine from the motor nerve terminal. The patient with LEMS develops muscle weakness, myalgias, and fatigability. LEMS predominantly involves the proximal muscles of the legs. Unlike MG, LEMS spares the extraocular muscles. The muscle strength is reduced at rest and transiently improves with repetitive muscle action. LEMS is associated with an antibody to the presynaptic calcium channel. Underlying cancer is found in 50-60% of persons with LEMS. In individuals with LEMS, the most commonly reported tumor is small cell lung cancer; however, thymoma has also been one of the associated neoplasms.

Subacute sensory neuronopathy

Subacute sensory neuronopathy is a rare disorder associated with small cell lung cancer and other thoracic malignancies, including thymoma and esophageal carcinoma. The patient develops painful paresthesias in the lower extremities that may ascend to involve the trunk and face. Marked sensory loss can lead to truncal ataxia, although motor strength is normal. The characteristic destruction of the dorsal root ganglia is believed to be antibody mediated.

Red cell aplasia

Of patients with thymoma, 5% develop pure red cell aplasia; 10-50% of patients with red blood cell aplasia have thymoma. Thrombocytopenia, granulocytopenia, and autoantibody formation are sometimes observed. In two thirds of individuals with red cell aplasia, morphologically, the thymoma is the spindle cell variety. Approximately 30% of patients with the disorder resume normal hematopoiesis after thymectomy.


Common variable immunodeficiency (CVID) with thymoma, Good syndrome, and immunodeficiency with thymoma are characterized by hypogammaglobulinemia or agammaglobulinemia in association with thymoma. Thymoma is associated with approximately 10% of hypogammaglobulinemia cases, and combined humoral and cell-mediated immunodeficiency is often noted. Immunodeficiency has been demonstrated to occur years after thymoma resection.

Good described Good syndrome in 1954. The syndrome usually occurs in individuals aged 40-70 years and only rarely occurs in children. However, an 8-year-old boy reportedly developed fatal chickenpox 4 months after resection of a benign thymoma. The immunodeficiency in Good syndrome affects both T and B lymphocytes, typically manifested as low B-cell numbers and inverted CD4+/CD8+ cell ratio. The thymic tumors are usually of the spindle cell type and are benign. Good syndrome is associated with recurrent bacterial sinopulmonary infections, chronic diarrhea of unclear etiology, and opportunistic infections. Autoimmune disorders are also associated with these acquired immunodeficiencies.

Hope this help..
Reply With Quote Quick reply to this message
The above post was thanked by:
Arhtur liu (11-30-2014), drbest (12-13-2010), lee-usmle (12-15-2010)
Old 12-13-2010
ashishkabir's Avatar
USMLE Forums Master
Steps History: 1+CK+CS+3
Posts: 625
Threads: 19
Thanked 369 Times in 220 Posts
Reputation: 389

This is a good post. Thanks aktorque!!
Reply With Quote Quick reply to this message
The above post was thanked by:
aktorque (12-13-2010)


Endocrine-, Pathology-

Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
HLA Associations Sabio USMLE Step 1 Mnemonics 11 11-01-2011 11:09 AM
Interesting Associations atr88 USMLE Step 2 CK Bits & Pieces 1 12-10-2010 08:03 AM
Mitral Valve Prolapse Associations and Risk Factors lee-usmle USMLE Step 2 CK Bits & Pieces 1 06-09-2010 12:22 PM
Pseudogout Associations Mnemonic khushboo USMLE Step 2 CK Mnemonics 0 06-07-2010 12:16 PM
Pyoderma Gangrenosum Associations sam01 USMLE Step 1 Bits & Pieces 0 05-14-2010 11:41 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2016 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)