Hyperestrinism and Liver Cirrhosis - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 12-23-2013
USMLE Forums Scout
 
Steps History: Not yet
Posts: 22
Threads: 11
Thanked 4 Times in 4 Posts
Reputation: 14
Question Hyperestrinism and Liver Cirrhosis

What are the causes of hyperestrinism ? and how its related to liver cirrhosis?
Reply With Quote Quick reply to this message



  #2  
Old 12-23-2013
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,109
Threads: 31
Thanked 520 Times in 394 Posts
Reputation: 539
Default

Quote:
Originally Posted by dr.laith View Post
What are the causes of hyperestrinism ? and how its related to liver cirrhosis?
In hepatic cirrhosis, becos of the disruption of the liver parenchema and fibrosis induced by TGF-b, there is decreased ability for the liver to detoxify the blood. Among such substances is oestrogen leading to hyperoestrinism with its attendant signs like gynecomasyia, spider angioma, testicular atrophy and Palmer erythema.
__________________
In USMLE, “Any fool can know. The point is to understand.”
Reply With Quote Quick reply to this message
  #3  
Old 12-23-2013
USMLE Forums Newbie
 
Steps History: CS Only
Posts: 4
Threads: 2
Thanked 0 Times in 0 Posts
Reputation: 10
Default

Hyperestrinism or Hyper-estrogen-ism can occur either due to increased productions (Eg Ovarian tumors, OCP, HRT, aromatase excess) or decreased metabolism (Eg Cirrhosis of Liver, decreased bile production). Due to fibrosis of liver tissues in Cirrhosis, and hence decreased function, it cannot conjugate Estrogen into its soluble form which would normally be excreted out in urine. Additionally, metabolism of steroids in also decreased in Cirrhosis which also increases the level of Estrogen.
Reply With Quote Quick reply to this message
  #4  
Old 08-21-2016
USMLE Forums Scout
 
Steps History: Not yet
Posts: 42
Threads: 9
Thanked 19 Times in 15 Posts
Reputation: 29
Default

Please see the following video for full explanation:
https://www.youtube.com/watch?v=XwuvuovXFpA

The explanations so far have been incorrect. Here is what happens:
1. The Liver becomes damaged, so the native Hepatic proteins are decreased
2. One of those proteins, Sex Hormone Binding Globulin (SHBG) decreases
3. Therefore, there is increased free estrogen (usually bound by SHBG)
4. Signs of Hyper-estrogenism --> Spider Angiomata, Gynecomastia, etc.
Reply With Quote Quick reply to this message
  #5  
Old 10-11-2016
USMLE Forums Newbie
 
Steps History: Not yet
Posts: 1
Threads: 0
Thanked 0 Times in 0 Posts
Reputation: 10
Default Hyperestrinism in cirrhosis

1. Since liver is damaged so metabolism of estrogen in liver decreases hence decreasing its excretion.
2. Androstenedione is not metabolised by liver and it is aromatised to estrone by adipose tissues which is later converted to estroadiol and induces production of sex hormone binding protein by uterus and testes which preferably binds to testosterone hence decreased free testosterone/estrogen ratio thus effects of hyperestrinism occur
Reply With Quote Quick reply to this message



Reply

Tags
Pathology-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
Liver Cirrhosis belindalimm USMLE Step 1 Forum 4 08-21-2016 06:40 AM
Liver cirrhosis question blade USMLE Step 1 Forum 5 11-26-2012 10:51 PM
Quinidine metabolism in a pt with liver cirrhosis Casandra USMLE Step 1 Forum 4 08-04-2012 07:37 AM
Hyperestrinism in Liver Cirrhosis Evergreen USMLE Step 1 Forum 5 01-17-2012 10:31 AM
Liver disease that does not need a Liver Biopsy? FSUSTC USMLE Step 2 CK Forum 7 04-27-2011 06:07 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)