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Old 01-04-2014
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Default polycystic ovarian syndrome

I read in kaplan qbank that PCOS has decreased FSH production so cause granulosa cell atrophy BUT in FA it is written that ther is Increase in estrogen level...
My question is as estrogen level is increasing ther should be granulosa cell hypertrophy NOT atrophy...
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Old 01-04-2014
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Originally Posted by medicalbiology View Post
I read in kaplan qbank that PCOS has decreased FSH production so cause granulosa cell atrophy BUT in FA it is written that ther is Increase in estrogen level...
My question is as estrogen level is increasing ther should be granulosa cell hypertrophy NOT atrophy...
Increase estrogen ins not from fsh stimulation it's from peripheral conversation of adipose into esto by lh
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Old 01-04-2014
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Originally Posted by medicalbiology View Post
I read in kaplan qbank that PCOS has decreased FSH production so cause granulosa cell atrophy BUT in FA it is written that ther is Increase in estrogen level...
My question is as estrogen level is increasing ther should be granulosa cell hypertrophy NOT atrophy...
U mean possible hyperplasia of granulosa cells. Not really.
Well, PCOS has increase estrogen becos LH is very high causing hyperandrogenism and subsequent aromatisation to estrogen peripherally.
The hyperestronism results in negative feedback inhibition on FSH. So if there is decrease in FSH production there would not be enough stimulus to cause granulosa cells to enlarge.
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