Q1) What happens to Aldosterone levels in a Cushing's patient? Will they go down because of the negative feedback inhibition from the weak mineralocorticoids?
Q2) What is the cause of polyuria in a Cushing's Patient? Is it because of osmotic diuresis from Hyperglycemia?
In cushings as there is a rise in mineralocorticoids, there should be retention of water and sodium right? Also hypokalemia as one of the causes of SIADH also should cause retention of water. Please explain why cushings cause polyuria.
Q3) Cushing Syndrome or Cushing Disease as we all studied, causes hirsutism because of increase in androgens. I cannot understand why there is an increase in androgens in primary (Adrenal Cause) cushings patient. In secondary cushings as there is an increase in ADH there is an increased production of cortisol, weak mineralocorticoid and also sex steroids. But why is there hirsutism in a primary cushings patient. Infact in primary as the cortisol levels are high, this should cause a decrease in ACTH leading to a decrease in sex steroids right?
Please explain anyone......