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Old 01-30-2014
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Default Phase 2 of depolarizing agents

Phase 2 of depolarizing agents is reversible by acetylcholine estrase inhibitors WHY??
In phase 2, receptors are desensitized so how more ach can reverse it?
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Old 01-30-2014
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Originally Posted by medicalbiology View Post
Phase 2 of depolarizing agents is reversible by acetylcholine estrase inhibitors WHY??
In phase 2, receptors are desensitized so how more ach can reverse it?
Ur right. It's simple in phase 1 u cannot reverse becos of the noncompetitive sustained blockade. But in phase 2 the blockade fades away with time. In phase 2 depolarising agent is just like a non depolarising agent which is easily reversible. Better understood with the train of four stimulation.
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