Hyperkalemia inhibits NH3 synthesis - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

Thread Tools Search this Thread Display Modes
Old 02-10-2014
USMLE Forums Scout
Steps History: Step 1 Only
Posts: 54
Threads: 22
Thanked 22 Times in 11 Posts
Reputation: 32
Send a message via Skype™ to yeshwanter
Default Hyperkalemia inhibits NH3 synthesis

I was reading BRS physiology..it said that Hyperkalemia inhibits NH3 synthesisand the conerse ocurs in hypokalemia..can anyone explain to me how this happens?
Thanks in advance
Reply With Quote Quick reply to this message

Old 03-26-2016
USMLE Forums Newbie
Steps History: Not yet
Posts: 2
Threads: 1
Thanked 0 Times in 0 Posts
Reputation: 10

When there is hyperkalemia, there will be increased shift of K+ from the ECF to ICF which is then excreted by the kidneys. To maintain electroneutrality, it will exchange with H+ present in the ICF which can lead to acidemia. This relationship goes both ways. (i.e. acidosis can cause hyperkalemia)
Now to your question, the increased K+ present in the renal tubular cells causes the pH of the cells to increase. The pH of renal tubular cells affects the enzymes involved in glutamine metabolism. An increased pH inhibits the enzymes leading to decreased NH3 formation and thus decreased H+ secretion => acidosis. And a decreased pH stimulates glutamine metabolism leading to increased NH3 formation and increased H+ secretion.
Reply With Quote Quick reply to this message


Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
hyperkalemia without ECG changes chienpolska USMLE Step 2 CK Forum 1 08-23-2012 11:15 PM
Hyperkalemia ethan_kien USMLE Step 1 Forum 1 08-18-2012 11:15 PM
Why Heparin causes Hyperkalemia! chienpolska USMLE Step 2 CK Forum 1 03-03-2012 10:06 PM
TG synthesis flowerlady USMLE Step 1 Forum 2 01-06-2012 03:46 AM
hyperkalemia medkary USMLE Step 1 Forum 7 07-30-2011 07:45 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2016 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)