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Old 02-20-2014
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Default Insulin Secretion

Hi!

I was wondering if NE increase insulin secretion or decrease it?

I've searched on the forums and I'm all seeing mixed answers.

Wouldn't it make sense in flight or fright situation it would increase insulin secretion, as most of the bodies tissues require insulin?

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Old 02-20-2014
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Norepinephrine will decrease insulin release (alpha-2 receptor mediated) while epinephrine will increase insulin release (beta receptor mediated). Overall effect of catecholamines would be a transient increase in blood glucose..
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Old 02-20-2014
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Arrow insulin secretion

Stimuli that increase cAMP levels in B cells increase insulin secretion, probably by increasing intracellular Ca2+. These include β-adrenergic agonists, glucagon, and phosphodiesterase inhibitors such as theophylline.

Catecholamines have a dual effect on insulin secretion; they inhibit insulin secretion via α2-adrenergic receptors and stimulate insulin secretion via β-adrenergic receptors. The net effect of epinephrine and norepinephrine is usually inhibition. However, if catecholamines are infused after administration of α-adrenergic blocking drugs, the inhibition is converted to stimulation.

(reference; ganong physiology)
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Old 02-22-2014
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Thanks a lot!
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